AXIS A Multi-catalysis, cascades and compartimentalization

Synthetic organic chemistry has considerably expanded in the last thirty years with the development of methods that theoretically enable the synthesis of any kind of complex natural products, even on a large scale. However, many issues remain to be addressed because new regulations and environmental constraints enforce to envision a more efficient organic synthesis that must combine the issues of conversion, selectivity, diversity and complexity with that of sustainability. The organic chemists should now include in their synthetic planning the notions of atom- and step-economy, toxicity of waste, energy cost, and recycling process. The design of multicatalytic cascades for the formation of complex molecules, to this end, can provide a solution to this challenge.

The search for modular catalytic systems able to mediate the formation of complex products, whose structure can be fine-tuned
according to the reaction conditions, should provide a unique tool to create libraries of high added value molecules from simple synthons ideally derived from biomass.
Accordingly, the main goal of this priority theme is the design of a chemical toolbox that allows for performing multi-catalyzed cascade transformations leading to the one pot formation of complex molecular architectures.
This challenging issue is addressed following different approaches:
- The design, synthesis and characterization of multifunctional catalysts,

- The design of multicatalytic systems through compartmentalization,

- The development of new cascade reactions towards molecular diversity and complexity.

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